The MC@CHOP is a state-of-the-art research and analytical facility that supports researchers at CHOP and throughout the Penn campus. We provide investigators with a resource that facilitates experimental and technical consultations as well as analysis of metabolites and metabolic pathways in humans and animal models, both in vivo and in vitro systems, to establish a better understanding of metabolomic and fluxomic statuses in normal and disease states as well as understanding drug handling and mechanism of action.